Hupsistos denotes the highest one in references to God and the highest realm in acclamations of glory or hosanna.

The dominant attested use designates God in clauses naming God, God’s power, or people as God’s Son, prophet, priest, or slaves. A further use occurs in acclamations that place glory, peace, or hosanna “in the highest,” using a plural neuter form.

1. God as the highest one · dominant

   The singular masculine forms occur in designations involving God: Acts 7:48 says that the Most High does not dwell in houses made by human hands, while Hebrews 7:1 calls Melchizedek priest of God the Highest. In Luke 1:32, Luke 1:35, and Luke 6:35, the APB renders clauses about the Son, the power, and the sons of the Highest.

   Acts 7:48Hebrews 7:1Luke 1:32Luke 1:35Luke 6:35Mark 5:7
2. The highest realm in acclamation · common

   The plural neuter dative form occurs in public praise formulas. In Luke 2:14 the APB renders “Glory to God in the highest,” and in Matthew 21:9, Mark 11:10, and Luke 19:38 it renders cries of hosanna, glory, or peace “in the highest.”

   Luke 2:14Matthew 21:9Mark 11:10Luke 19:38

In the Anselm Project Bible: The APB commonly presents the singular masculine forms as “the Highest” or “the Most High,” including “God the Highest.” For the plural neuter dative forms it uses “in the highest”; these renderings reflect whole translated clauses.