Kataphroneo is used for treating people, authority, divine kindness, or shame with dismissive contempt.

The term consistently marks a dismissive stance toward an object of regard: people may be treated with contempt, masters and authority rejected, God’s kindness slighted, or shame set aside. In the two-slaves saying, it names the rejection of one master in favor of the other.

1. Treating someone or something with contempt · dominant

   In 1 Corinthians 11:22, the present plural form occurs in the question about the church of God and stands alongside the humiliation of those who have nothing; the APB renders the clause “do you despise the church of God.” In Matthew 18:10 it is forbidden toward “one of these little ones,” while in 1 Timothy 6:2 it is prohibited toward believing masters. The term also concerns rejecting lordship in 2 Peter 2:10, slighting God’s kindness, tolerance, and patience in Romans 2:4, and treating the cross’s shame as contemptible in Hebrews 12:2.

   1 Corinthians 11:22Matthew 18:101 Timothy 6:22 Peter 2:10Romans 2:4Hebrews 12:2

In the Anselm Project Bible: The APB repeatedly uses “despise,” including for the church of God, little ones, masters, lordship, divine kindness, and one of two masters. In 1 Timothy 4:12 it instead renders the clause “Let no one look down on you,”.