egkakeo describes not yielding to discouragement or weariness while praying, doing good, or enduring pressure.

The occurrences consistently describe refusing to yield to discouragement or weariness: amid ministry and bodily decline, while praying, under pressure, and in continuing to do good. The wording varies by clause, but the supplied verses support one attested use rather than separate lexical senses.

1. Not yielding to discouragement or weariness · dominant

   In 2 Corinthians 4:1 and 2 Corinthians 4:16, the present first-person plural forms occur in declarations that the speakers do not lose heart, despite ministry and the destruction of the outer person. In Galatians 6:9 and 2 Thessalonians 3:13, the clauses prohibit giving up or growing weary in doing good; Luke 18:1 links the infinitive with continual prayer, and Ephesians 3:13 with pressures endured for others.

   2 Corinthians 4:12 Corinthians 4:162 Thessalonians 3:13Ephesians 3:13Galatians 6:9Luke 18:1

In the Anselm Project Bible: The APB presents the clauses with “lose heart,” “be discouraged,” “grow weary,” and “give up.” These are verse-level renderings rather than fixed English equivalents for the lemma.