ktisis denotes the created order, a new creation, and in particular clauses a created entity or human institution.

The dominant usage denotes the created order in relation to its beginning, its scope, its condition, and its relation to God. Two verses use it with “new” for a changed reality, while particular clauses also place it in reference to a human institution or a creature set beside the Creator.

1. The created order as a whole · dominant

   The genitive singular κτίσεως marks the beginning of the created order in Mark 10:6 and its relation to the world in Romans 1:20; in Colossians 1:23, the dative singular κτίσει is used in the clause about proclamation “in all creation under heaven.” In Romans 8:20 and Romans 8:22, nominative singular κτίσις is the subject that is subjected to futility and that groans together; Hebrews 4:13 places no creation outside God's sight.

   Mark 10:6Romans 1:20Colossians 1:23Romans 8:20Romans 8:22Hebrews 4:13
2. A new creation · occasional

   In 2 Corinthians 5:17, nominative singular κτίσις stands in the statement that, if anyone is in Christ, there is “a new creation,” followed by the passing of ancient things and the coming of new things. Galatians 6:15 likewise contrasts circumcision and uncircumcision with “a new creation.”

   2 Corinthians 5:17Galatians 6:15
3. A particular created entity or institution · occasional

   In 1 Peter 2:13, dative singular κτίσει occurs in the instruction to submit to every human institution. In Romans 1:25, the dative singular appears in the contrast between worshiping and serving “the creature” and the Creator; the translation’s precise assignment of English wording to the term is not explicit.

   1 Peter 2:13Romans 1:25

In the Anselm Project Bible: The APB commonly presents the term with “creation,” including “all creation” and “the creation,” and uses “new creation” in 2 Corinthians 5:17 and Galatians 6:15. It also has “human institution” in 1 Peter 2:13 and “the creature” in Romans 1:25.