to mistreat
epereazo describes hostile treatment directed at people, answered with prayer or upright conduct.
The two present active participles describe people who direct hostile treatment toward others: in Luke 6:28 they are the people for whom prayer is commanded, while in 1 Peter 3:16 they stand within a clause about opponents being put to shame by good conduct.
Senses in use
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Hostile treatment directed at others · dominant
Both occurrences use a present active participle for people acting against others. In Luke 6:28 the APB renders the clause "pray for those who mistreat you"; in 1 Peter 3:16 the surrounding clause concerns those who slander and are put to shame by good behavior.
In the Anselm Project Bible: The APB explicitly uses "mistreat you" in Luke 6:28. In 1 Peter 3:16 it presents the surrounding opposition as slander and shame.