to reject
exoutheneo is used of dismissing people or things with contempt, treating them as unworthy of regard.
The occurrences show dismissal or contempt directed toward people, a prophecy, and a stone: believers are warned not to look down on one another, hearers are told not to dismiss prophecy, and persons or things may be portrayed as rejected or treated with contempt.
Senses in use
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Dismissing with contempt or disregard · dominant
In Romans 14:3 and Romans 14:10, the active forms occur in warnings and questions about despising a fellow believer. In 1 Corinthians 16:11 and Galatians 4:14, the clauses concern not treating a person with disregard; Luke 23:11 describes Herod's contemptuous treatment, while Acts 4:11 uses an aorist passive participle of the stone rejected by the builders.
In the Anselm Project Bible: The APB variously uses "despise," "reject," "treated him with contempt," and "of no account" in verses containing the term. These expressions present the clauses' overall portrayal rather than fixed individual renderings.