to leave behind
egkataleipo denotes leaving someone or something without presence, support, or continued attachment.
The occurrences show leaving or being left in ways that withdraw presence, support, or continued attachment: people desert a defendant, Demas leaves, a gathering is neglected, and divine speech denies leaving. The same pattern appears in statements that a soul was not abandoned and in cries asking why God had forsaken the speaker.
Senses in use
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Leaving without support or continued attachment · dominant
Across the occurrences, the verb marks withdrawal from a person, place, practice, or condition. In 2 Timothy 4:16 the aorist active plural form occurs where all deserted the speaker at his defense; in Hebrews 10:25 the present active participle occurs in the warning not to neglect meeting together. In Acts 2:27 the future active form is denied of a soul being abandoned to Hades, while in Matthew 27:46 the aorist active singular form occurs in the cry asking why God had forsaken the speaker.
In the Anselm Project Bible: The APB varies its verse-level wording between “forsaken,” “left,” “deserted,” “abandon,” and “neglecting.” These renderings indicate the clauses' varied contexts rather than separate lexical meanings.