to harden
qa.shach describes making a heart unresponsive or treating sons harshly in the two attested contexts.
The two occurrences show a causative action of hardening or harshening: in Isaiah it concerns a heart that does not fear, while in Job it describes harsh treatment of sons.
Senses in use
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Hardening a heart against fear · dominant
In Isaiah 63:17, the Hiphil imperfect addresses the LORD concerning the heart becoming such that it does not fear. The APB renders the clause, "Why do you harden our heart so that we do not fear you?"
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Treating sons harshly · occasional
In Job 39:16, the Hiphil perfect describes a female subject's treatment of her sons as though they were not hers. The APB renders the verse, "She deals harshly with her sons as though they were not hers."
In the Anselm Project Bible: The APB presents the action as "harden" in Isaiah 63:17 and "deals harshly" in Job 39:16. These renderings confirm the clauses' overall presentation rather than establish separate English equivalents.