anguish
Odune denotes deep personal distress, expressed as inward sorrow or as many painful afflictions.
The two verses show personal distress in two settings: unceasing anguish located in the heart and many griefs brought upon oneself.
Senses in use
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Inward, unceasing sorrow · dominant
In Romans 9:2, the nominative singular form occurs in the clause describing anguish in the speaker's heart as unceasing; the APB renders the verse, "that my grief is great and the anguish in my heart is unceasing."
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Many self-inflicted griefs · occasional
In 1 Timothy 6:10, the dative plural form occurs where those reaching after money have pierced themselves with many griefs; the APB renders the clause "have pierced themselves with many griefs."
In the Anselm Project Bible: The APB presents the two clauses with "anguish" in Romans 9:2 and "many griefs" in 1 Timothy 6:10. These render the verses' presentation rather than establish separate lexical definitions.