to set off
epanago describes setting out or moving off, whether a boat leaves the land or a person heads toward a city.
The attested use describes setting out or moving away in a directed movement: a boat is to move from the land and into deep water in Luke 5:3 and Luke 5:4, while a traveler is setting off toward the city in Matthew 21:18.
Senses in use
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Setting out or moving off toward a destination · dominant
In Luke 5:3, the aorist active infinitive occurs in the request concerning Simon's boat, which the APB renders as putting out a little from the land; Luke 5:4 uses an aorist active singular command for movement into the deep. In Matthew 21:18, the present active participle describes movement toward the city, where the APB renders the clause “setting off toward the city.”
In the Anselm Project Bible: The APB presents the Luke clauses as “put out” from land and “Put out into the deep,” and Matthew 21:18 as “setting off toward the city.” These phrases confirm the movement in each clause rather than supply a separate definition.